Therapeutic update in eosinophilic esophagitis

Eosinophilic esophagitis is a chronic disease characterized clinically by symptoms of esophageal malfunction and histologically by infiltration of…

Eosinophilic esophagitis is a chronic disease characterized clinically by symptoms of esophageal malfunction and histologically by dense infiltration by eosinophilic leukocytes. Its etiology is immunoallergic and is triggered in most cases by a non-IgE mediated food allergy. It is now a common disease in Europe, the United States and Australia, and emerging in South America and Asia. During the last decade there have been substantial improvements in the therapeutic algorithm of the disease, from the inclusion of proton pump inhibitors as an anti-inflammatory drug, the emergence of new topical corticosteroids designed specifically for the disease, the simplification and optimization of elimination diets and the acceptance of endoscopic dilatation as a highly effective and safe adjuvant treatment. This review attempts to update and imbricate, from a practical point of view, the main therapeutic options available for this new and intriguing disease.

Keywords. Eosinophilic esophagitis, proton pump inhibitor, corticosteroids, diet, dilatation.

Javier Molina-Infante, Rodolfo Corti, Judith Doweck, Alfredo J Lucendo
Acta Gastroenterol Latinoam 2018;48(3):242-252

Publisher: Revista Acta Gastroenterológica Latinoamericana.

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